Pamaquine|Structure|Synthesis|Mechanism of action |Uses |Side-effects|Plasmoquine|Pamaquin|Praequine|Plasmochin|Plasmocide|Rhodoquine|Aminoquine|Beprochin |

 Pamaquine

Pamaquine is a 8-aminoquinolin drug that is closely related to primaquine. It was earlier used for the treatment of malaria. The moleculer weight of Pamaquine is 315.5g/mol. It is also known as Plasmoquine, Pamaquin, Praequine, Plasmochin, Plasmocide, Rhodoquine, Aminoquine, Beprochin etc.

■Structure:

The moleculer formula of Pamaquine is,  [C19H29N3O]

The IUPAC name of Pamaquine is, 1-N, 1-N-diethyl-4-N-(6-methoxyquinolin-8-yl)pentane-1,4-diamine 

■Synthesis:

■Mechanism of action:

The moa of Pamaquine is not yet clear. Ii is assumed to generate active oxygen species , interfere with the electron transport in the parasite, or bind to and alter the properties of protozoal DNA.

■Uses:

It is effective against the hypnozoites  of the relapsing malaria P.vivax and P.ovale. It is also effective against the erythrocytic stages of all four types of human malaria. 

■Side-effects:

The major Side-effects of Pamaquine are,

• It cause haemolytic anaemia in patients with G6PD deficiency. 
• Vomiting. 
• Nausea. 
• Epigastric distress.
• Abdominal cramps. 

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